Computer Methods by Michael L. Johnson and Ludwig Brand

By Michael L. Johnson and Ludwig Brand

The combo of swifter, extra complicated desktops and extra quantitatively orientated biomedical researchers has lately yielded new and extra exact tools for the research of biomedical info. those larger analyses have improved the conclusions that may be drawn from biomedical information, and so they have replaced the best way that experiments are designed and played. This quantity, in addition to past and coming near near 'Computer equipment' volumes for the tools in Enzymology serial, goals to notify biomedical researchers approximately contemporary functions of contemporary info research and simulation tools as utilized to biomedical learn.

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100 ms) in a deafferented locust with pulse duration Pd ¼ 25–30 ms and pulse strength Ps ¼ 10 nA. (e) Insect communication: Normally the most critical maskers—and signals that cause entrainment—are the sounds of other conspecifics. Hence, the species-specific chirp is typically used as the perturbation signal. 3 s). In cases where the duration of the sound chirp is large compared to the chirp period, however, it may not be possible to use the species-specific signal. After a male begins to sing, the disturbance pulses are played back via a loudspeaker at various phases of its chirp rhythm.

Fortunately, PRCs provide predictions on the dynamical properties of oscillators. For example, measuring a type 0 PRC suggests that a reduction of the pulse strength should lead to a type 1 PRC, and specific perturbations might lead to a phase singularity (Winfree, 1980). An even more powerful prediction concerns bifurcations of coupled oscillators. As illustrated nicely in Guevara et al. (1981) and Hartbauer et al. (2005), the measurement of PRCs leads to quantitative predictions of p:q frequency locking and alternations.

The revolutions of the running wheel are counted, and phases f and periods T of locomotor activity are derived. For a review of PRCs in the field of circadian clocks, see Johnson (1999). (b) Heart rhythms: Normal heart rhythms are triggered by pacemaker cells of the sinus node. The period T0 is typically in the order of 1 s and can be regulated by autonomous neuronal activity. Human electrocardiograms measure heart activity directly. , 1981), intracellular electrodes record transmembrane potentials with an amplitude A0 of about 100 mV.

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