Contrast Media in Radiology: Appraisal and Prospects by E. C. Lasser (auth.), Prof. Dr. Michel Amiel (eds.)

By E. C. Lasser (auth.), Prof. Dr. Michel Amiel (eds.)

Journalists, continuously very direct and looking for sensation, basically requested me questions about the social gathering of this workshop: What have been the targets of the assembly? With the advance of prognosis throughout the improvement of picture strategies, did not the distinction media have already got their destiny in the back of them? Many solutions have been supplied through the process the workshop, and in an effort to most sensible resolution the newshounds I proposed the subsequent synopsis. 1. because the 1979 Colorado Springs workshop geared up by way of E. Lasser, growth has been so quick and the newly on hand works so various that one other assembly on a global point for the aim of pre­ senting and discussing those advances seemed crucial. Why no longer then in Europe and why no longer in Lyon? To extend in this development, through 1981 the recent distinction media with less-hyperosmolar molecules, nonetheless within the trial level in 1979, have been al­ so much all to be had commercially for angiography, albeit at prohibitive costs. the benefits of those a variety of media have gotten larger recognized; in addition, within the wake of Lasser's paintings, our realizing of the pathophysiology in their noxious results is additionally advancing swiftly due to using types (for the objective organs: middle, vessel wall, apprehensive approach, kidney; and for the extra common reactions: blood cells, coagulation, supplement process, circulating enzymatic systems). additionally, extra new molecules are at the moment being studied in re­ seek laboratories. 2.

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The supernatant was collected for the following studies. Study of Isoenzyme Distribution in each Layer For each layer, protein content was measured using Gornall's method [4]. Total CPK activity was measured by the CK-NAC test (Boehringer activated UV system) at 30°C. The reaction was allowed to continue for 4-5 min: under these conditions kinetics were ordered zero. The wavelength chosen to avoid any speCtrum interference from the contrast agents was 366 nm. Results are expressed in international units (IV).

1). Dia· trizoic acid and amidotrizoic acid, two very similar products, were also responsible for a significant decrease of complement at 90 s, followed by a progressive correction of the altered values (Figs. 2, 3). Iopamidol and ioxaglic acid also led to a significant decrease in several complement components, but this diminution appeared to be of a lesser mag· nitude and was fully compensated after 30 min (Figs. 4, 5). 20 ... , ' 30 II. '" '" + CHSO t C3 ', ++ Clq t +. + II. '0. 13. n. 0 e t +.

EDTA-free RCM preparations triggered the same anticoagulant effects as their commercial EDTA-containing counterpart. Changes of Thrombin Activity by RCM Fresh pool sera exhibit substantial thrombin activity. Incubation of these sera by rising concentrations of RCM resulted in no (nephrotopic) or only very delayed impairment of thrombin activity (hepatotropic RCM). Parallel determinations of thrombin activity and thrombin time were made after a purified human fibrinogen solution (250 mg%) had been incubated with rising concen- 32 (sec) c u 150 luO B 10 50 70 100 [mM) Fig.

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